Featuring the first structured fixed-bed design, the scale-X bioreactor portfolio solves the challenges of capacity and scalability in a reduced physical footprint. The bioreactors create a truly homogeneous environment to increase cell density without aggregation while boosting specific productivity to make each cell deliver more.
Exploratory technical illustration shows a bioreactor vessel (left), a high-efficiency temperature control system, or ‘jacket’, for heating/cooling (top right) and an optimized propeller design
Membrane bioreactors have become an attractive option for the treatment and reuse of industrial and municipal wastewater, as evidenced by their consistently rising numbers and capacity. The current membrane bioreactor market was estimated to be worth around US $216 million in 2006 and US$838.2 million in 2011, grounding projections that the
The Thermo Scientific HyPerforma Single-Use Bioreactor (S.U.B.) is widely adopted in process development (PD), clinical trials, and cGMP cell culture production. The design and features of the HyPerforma S.U.B. have been steadily improved since its launch in 2006 to meet the increasing performance demands required by current cell culture
With the microgroove design, the cell viability was much higher resulting in a more stable production of albumin and urea over a 4-day culture period when compared to the flat substrate bioreactors. 61 In order to increase the cellular capacity of the bioreactor without introducing oxygen deprivation, stacked microgrooved plates in a radial
years a huge number of different bioreactor concepts have been developed. As the main problem for designing a scalable bioreactor concept, the high shear sensitivity of the cells have to be considered (compare Sect. 4.1). For example, stirred-tank bioreactors can be operated at low impeller speed and low aeration rate only, result-
Diagram of a bioreactor process showing key factors that can influence kLa values. 3. Air flow rate. Higher oxygen availability drives kLa increases. Increasing oxygen supply to a bioreactor drives this availability and can be controlled by modifying concentration (air vs O 2 enrichment) and volumetric flow.
Feb 7, 2024 · Bioreactor scale-up influences physical, chemical, and biological factors of cell culture. Physical factors, as mentioned above, include bioreactor configuration, aeration, agitation, heat transfer/removal, and mixing. Chemical factors affected by scale-up include type and concentration of acid/base needed for pH control, water quality, and
Productivity of a bioreactor is the quantity of product produced per unit volume in unit time. For a batch bioreactor with the growth profile shown in Fig. 29, the biomass productivity P at any time t is the slope of the straight line joining the biomass concentrations at t = t and t = 0 in Fig. 31; i.e.,
Apr 30, 2018 · This has spawned a demand for bioreactors capable of supporting industrial-scale, ultra-high-density cell suspension cultures with controlled microenvironments, standardization, and uniformity of culture conditions in order to generate homogenous populations of stem or lineage-specific cells.
Sep 15, 2018 · Among these facilities, most current capacity is used for manufacturing viral vectors used with gene therapy, including some facilities having scaled up to bioreactors of 1,000-L to 2,000-L scale (4). By contrast, capacity used for cellular therapies generally remains at much lower scales, with many sites manufacturing just a single patient’s
Jun 15, 2016 · High SRTs produce starvation conditions in the bioreactor creating an enabling environment for reduced formation of EPS, low sludge production and nitrification [5,69]. However, extremely high SRTs are not desirable as they rather increase membrane fouling due to the accumulation of matters (high MLSS accumulation) and increasing sludge
The bioreactor is a large vessel where the different cells such as human or plant, or animal cells can be cultured to obtain new biological products. It provides optimum conditions like temperature, pH, substrate, oxygen, etc required for the culturing of cells producing desired products. Simple stirred-tank bioreactor and sparged stirred-tank
Dec 11, 2019 · It has been demonstrated that high performance efficiency (more than 80% BOD destruction/o-cresol removal) is attained within a low reactor volume (D = 0.5 m, L Sf = 1.2 m) at high capacities (as high as 82,000 L h − 1). Another interesting feature reported is that in these bioreactors, the fractional substrate conversion (α) increases with
Aug 8, 2022 · 1 Introduction. Bioreactors play an important role in the production of large-scale viral vaccines in cell culture ().With the advance of vaccine production process, increasing numbers of scalable bioreactors and cell lines with high affinity for viruses have been applied for the production of different vaccines.